"Maybe meeting Paul McCartney or the Queen? I played at the Queen's Jubilee. It was really cool," he said.
The British star also recalled a recent time where he got to play poker with Bill Clinton the other day calling it pure "random".
"I bought a saxophone and got him to sign it," he added. "De Niro, that was a big one. I played the opening of De Niro's hotel."
Ed caused a stir with his Lord Or The Rings sword on a plane with Taylor Swift earlier this year and said meeting the director of the movie was fantastic.
"Peter Jackson, the guy who did the Lord of the Rings films, he invited us around for dinner. Just a lot of random wicked things have happened. It generally is the greatest job ever. Every single day there's something mental that happens," he continued.
Meanwhile, Ed is currently on the road with Taylor Swift and recently was named among the nominations for the MTV VMAs 2013.